Description
Product Characteristics: FUNCTION: Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K+. May be involved in sperm capacitation and/or the acrosome reaction, essential steps in fertilization where changes in both intracellular pH and membrane potential are known to occur. In contrast to KCNMA1/SLO1, it is not activated by Ca2+ or Mg2+. Subcellular location: Membrane, Multi-pass membrane protein Tissue specificity: Testis-specific. Mainly expressed in spermatocytes. Detected in brain and brainstem, in vestibular and oculomotor nuclei, the medial nucleus of the trapezoid in the auditory system, in olfactory bulb, red nucleus, and deep cerebellar nuclei. Detected in thalamus, substantia nigra, and amygdala (at protein level). Highly expressed in the brain and kidney. Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle.,Calcium-activated,Potassium channel subfamily T member 1, KCa4.1, SLACK
Target Information: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]